Acute treatments include:

Oxygen. Briefly inhaling 100 percent oxygen through a mask at a rate of 6 to 8 liters a minute provides dramatic relief for most who use it. Occasionally, a higher flow rate may

be more effective. The effects of this safe, inexpensive procedure can be felt within 15 minutes. The major drawback of oxygen is the need to carry an oxygen cylinder and

regulator with you, which can make the treatment inconvenient and inaccessible at times. Small, portable units are available, but some people still find them impractical.

Sometimes, oxygen may only delay rather than stop the attack, and pain may return.
Sumatriptan. The injectable form of sumatriptan (Imitrex), which is commonly used to treat migraine, is also an effective acute treatment for cluster headache. Some people may

benefit from using sumatriptan in nasal spray form, but for most this is not as effective as an injection. Sumatriptan isn't recommended for people with uncontrolled high blood

pressure or ischemic heart disease.

Another triptan medication, zolmitriptan (Zomig), can be taken orally for relief of cluster headache. Although oral zolmitriptan isn't as effective as injectable sumatriptan, it

may be an option for people who can't tolerate other forms of acute treatment. Zolmitriptan also is available in nasal spray form.

Dihydroergotamine. This ergot derivative is available in intravenous, injectable and inhaler forms. Dihydroergotamine (D.H.E. 45, Migranal) is an effective pain reliever for

some people with cluster headache. When administered intravenously, the drug requires you to go to a hospital or doctor's office to have an intravenous (IV) line placed. The

inhaler form of the drug works more slowly. The dosage must be limited to avoid side effects, especially nausea.
Octreotide (Sandostatin, Sandostatin LAR). This drug, a synthetic version of the brain hormone somatostatin, has traditionally been used to control severe diarrhea. However,

some studies have shown that the injectable form is an effective treatment for cluster headache and is safe for people with high blood pressure and ischemic heart disease.
Local anesthetics. The numbing effect of local anesthetics, such as lidocaine (Xylocaine), may be effective against cluster headache pain when used in the form of nasal drops.
Surgery
Rarely, surgery is recommended for people with chronic cluster headache who don't respond well to aggressive treatment or who can't tolerate the medications or their side

effects. Candidates for surgery must have headaches only on one side of the head because the surgery can be performed only once. People with headaches that alternate sides of

the head risk the chance that the procedure will be unsuccessful.

Several types of surgery have been used to treat cluster headache. These procedures attempt to damage the nerve pathways thought to be responsible for pain. However, residual

muscle weakness in your jaw or sensory loss in certain areas of your face and head may result. The most common procedures are directed at the trigeminal nerve. They include:

Conventional surgery. Using a conventional invasive procedure, your surgeon cuts part of the trigeminal nerve with a scalpel or uses small burns to destroy part of the nerve.

This form of surgery provides relief for most people with chronic cluster headache.
Radiosurgery. In a procedure called radiosurgery, a focused beam of radiation is used to destroy part of the trigeminal nerve. Radiosurgery is a noninvasive procedure that may

have fewer side effects than does conventional surgery, but some studies have questioned the effectiveness and permanency of the results.
Potential treatments
As scientists learn more about the causes of cluster headache, they're able to develop more selective treatments for the condition. One development that shows promise is the use

of a device to stimulate the occipital nerve, which influences the trigeminal nerve. To treat people with frequent cluster headaches, researchers are testing a stimulator — a

pacemaker-sized device that sends impulses via electrodes — that is implanted over the occipital nerve. A Mayo Clinic study of implanted occipital nerve stimulators found that

the devices reduced chronic headache pain by an average of about half.

Similar research is under way using an implanted stimulator in the hypothalamus, the area of the brain associated with the timing of cluster periods. Stimulation of the

hypothalamus in a small number of people with severe, chronic cluster headaches has produced complete and long-term pain relief with no significant side effects.

Treatment
There's no cure for cluster headaches. The goal of treatment is to help decrease the severity of pain and shorten the headache period.

Acute medication
The purpose of acute treatment is to stop or reduce pain after a cluster headache starts. Because the headache peaks quickly, acute medications must be fast-acting and delivered

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